运动联合补中助长颗粒治疗特发性矮小症临床研究
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R729

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河南省科技攻关项目(182102310395);河南省医学科技攻关项目(2018020534)


Clinical Study on Exercise Combined with Buzhong Zhuzhang Granules for Idiopathic Short Statue
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    摘要:

    目的:观察运动联合补中助长颗粒治疗特发性矮小症 (ISS) 的临床疗效。方法:将 76 例 ISS 患儿随机分为观察组和对照组各 38 例。对照组给予口服补中助长颗粒治疗,观察组在对照组基础上联合中等强度舒展性运动治疗,2 组均治疗 12 个 月。比较 2 组身高、身高增长速度 (GV)、身高落后标准差 (HtSDS)、体质量指数 (BMI)、年龄/骨龄 (CA/BA) 及血清生长激素峰值(GHP)、血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白 3(IGFBP3)水平,观察治疗期间不良反应发生率。结果:治疗 12 个月,观察组 HtSDS 大于对照组,差异有统计学意义(P<0.05)。治疗 6 个月、12 个月,观察组 GV 大于对照组,血清 IGF-1、IGFBP3 水平均高于对照组,差异均有统计学意义 (P<0.05);2 组身高、BMI、CA/BA 及血清 GHP 水平比较,差异均无统计学意义(P>0.05)。2 组治疗期间均无不良反应发生。结论:运动联合补中助长颗粒能有效促进 ISS 患儿生长,其作用机制可能与促进血清 IGF-1、IGFBP3 水平升高有关,临床使用安全。

    Abstract:

    Abstract:Objective:To observe the clinical effect of exercise combined with Buzhong Zhuzhang granules for idiopathic short statue(ISS). Methods:A total of 76 cases of ISS children were randomly divided into the observation group and the control group,38 cases in each group. The control group was given oral administration of Buzhong Zhuzhang granules,and the observation group was additionally treated with stretching exercise with moderate intensity based on the treatment of the control group. Both groups were treated for 12 months. The comparison of height, growth rate(GV), height standard deviation score(HtSDS), body mass index(BMI), chronological age/bone age(CA/BA), as well as the levels of growth hormone peak(GHP),insulin-like growth factor-1(IGF-1),and insulin-like growth factor binding protein 3(IGFBP3) in serum were conducted between the two groups. The incidence of adverse reactions during treatment was observed. Results:After twelve months of treatment,the HtSDS was larger than that in the control group,difference being significant(P<0.05).After six months and twelve months of treatment,the GV in the observation group were larger than those in the control group, and the levels of IGF-1 and IGFBP3 in serum were higher than those in the control group,differences being significant(P<0.05). After six months and twelve months of treatment,there were no significant differences being found in the comparison of height,BMI,CA/BA,and the level of GHP in serum between the two groups(P>0.05). No adverse reaction occurred in the two groups during treatment. Conclusion: The therapy of exercise combined with Buzhong Zhuzhang granules can effectively promote the growth of ISS children with safe clinical use,whose mechanism is probably related to its promotion on the increase of levels of IGF-1 and IGFBP3 in serum.

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孙凤平,崔伟锋,李宁宁,韩雪.运动联合补中助长颗粒治疗特发性矮小症临床研究[J].新中医,2020,52(23):69-72

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  • 在线发布日期: 2020-12-09
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