Abstract： Objective： To observe the clinical effect of Yishen Huazhuo tang combined with nimodipine for vascular dementia and its effect on cerebral blood flow and inflammatory indexes. Methods： A total of 76 cases of patients with vascular dementia were randomly divided into the control group and the observation group， 38 cases in each group. The control group was treated with nimodipine，and the observation group was additionally treated with Yishen Huazhuo tang based on the treatment of the control group. Both groups were treated for three months. The clinical effect，the mean blood flow of middle cerebral artery(MCA) ，anterior cerebral artery(ACA)，posterior cerebral arteries(PCA)，vertebral artery(VA) and basilar artery(BA) in both sides of the brain，and the levels of tumor necrosis factor-α(TNF-α)，interleukin-6(IL-6) and highsensitivity C-reactive protein(hs-CRP) in the two groups were observed and compared. Results：The total effective rate was 89.47% in the observation group and 68.42% in the control group，the difference being significant(P＜0.05). After treatment， the blood flow velocity of MCA，ACA，PCA，VA and BA in both sides in the two groups were increased when compared with those before treatment(P＜0.05)，and the increase in the observation group was more significant than that in the control group (P＜0.05). After treatment， the levels of TNF- α， IL- 6 and hs- CRP in serum in the two groups were decreased when compared with those before treatment(P＜0.05)，and the decrease in the observation group was more significant than that in the control group(P＜0.05). Conclusion：The therapy of Yishen Huazhuo tang combined with nimodipine for vascular dementia has significant curative effect， and can effectively improve supply of cerebral artery blood flow and relieve inflammatory responses.