Abstract： Objective： To observe the curative effect of Qufeng Huatan and Tongluo Zhijing method combined with western medicine for idiopathic facial paralysis(IFP) with wind-cold assailing the collaterals syndrome at acute stage，and its effect on conduction function of facial nerve and related cytokines. Methods： A total of 110 cases of IFP patients with wind-cold assailing the collaterals syndrome at acute stage were selected as the study subjects，and were divided into the observation group and the control group according to the order of admission，55 cases in each group. The control group was given antiviral medicine， glucocorticoid and nerve nutritional agents， and the observation group was additionally given acupuncture with Qufeng Huatan and Tongluo Zhijing method as well as oral administration of Chinese medicine based on the treatment of the control group. The facial nerve function，conduction function of facial nerve，and the levels of glial cell linederived neurotrophic factor(GDNF) and nerve growth factor(NGF) in serum were compared between the two groups. The clinical effect was evaluated. The incidence of adverse reactions was recorded. Results： After treatment， the scores of lagophthalmos and deviation of angle of mouth in the two groups were decreased(P＜0.05)， and the two scores in the observation group were lower than those in the control group(P＜0.05). After treatment，M-wave latency of frontal muscle， orbicularis oculi muscle and orbicularis oris muscle in the two groups was decreased(P＜0.05)，and the M- wave latency in the observation group was lower than that in the control group(P＜0.05). After treatment， the levels of GDNF and NGF in serum in the two groups were increased(P＜0.05)，and the two levels in the observation group were higher than those in the control group(P＜0.05). After treatment， the Chinese medicine syndrome scores in the two groups were decreased(P＜ 0.05)，and the scores in the observation group were lower than those in the control group(P＜0.05). The total effective rate was 89.09% in the observation group，significantly higher than that of 72.73% in the control group(P＜0.05). The incidence of adverse reactions was 9.09% in the observation group， 0 in the control group， and there was significant difference being found in the comparison of the incidence of adverse reactions between the two groups(P＜0.05). Conclusion：For IFP patients with wind-cold assailing the collaterals syndrome at acute stage，the therapy of Qufeng Huatan and Tongluo Zhijing method combined with western medicine can significantly improve curative effect and Chinese medicine syndrome，and promote the recovery of facial nerve function. Its mechanism may be related to its enhancement to the expression of GDNF， NGF and other growth factors.