肠益煎辅助化疗对大肠癌术后癌因性疲乏、免疫功能影响的研究
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R735.34

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Study on Effect of Changyi Jian Assisting Chemotherapy on Cancer Related Fatigue and Immune Function After Surgery for Colorectal Cancer
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    摘要:

    目的:观察肠益煎辅助常规化疗对大肠癌术后患者免疫功能及癌因性疲乏(CRF) 的干预效果。方法:使用随机数字表法将84 例大肠癌术后患者分为治疗组和对照组,各42 例。2 组在常规FOLFOX4(氟尿嘧啶、亚叶酸钙及奥沙利铂灌注)化疗的基础上,对照组予对症支持治疗,治疗组予对症支持治疗+肠益煎治疗,均治疗3 个月。对比2 组治疗前后癌症疲乏量表(CFS) 评分、外周血T 淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+及治疗后白细胞下降、血小板减少、血红蛋白减少例数。结果:与同组治疗前比较,治疗后2 组躯体疲乏及总疲乏CFS 评分均降低(P<0.05),且治疗组低于对照组(P<0.05)。与同组治疗前比较,治疗后2 组CD4+、CD3+及CD4+/CD8+水平降低(P<0.05),CD8+水平升高(P<0.05);与对照组治疗后比较,治疗组CD4+、CD3+及CD4+/CD8+水平升高(P<0.05),CD8+水平及白细胞下降例数降低(P<0.05)。结论:肠益煎辅助化疗治疗大肠癌术后患者,可有效改善患者的CRF 状态及免疫功能,且骨髓抑制较少。

    Abstract:

    Abstract: Objective: To observe the intervention effect of Changyi jian assisting routine chemotherapy on immune function and cancer related fatigue(CRF) in patients after surgery for colorectal cancer. Methods: A total of 84 cases of patients who underwent surgery for colorectal cancer were divided into the treatment group and the control group according to the random number table method, 42 cases in each group. Both groups were given routine FOLFOX4 chemotherapy, which was the perfusion of fluorouracil, calcium folinate and oxaliplatin; the control group was additionally given symptomatic and supportive treatment;the treatment group was additionally given Changyi jian based on the treatment of the control group. Both groups were treated for three months. Before and after treatment,the scores of Cancer Fatigue Scale (CFS), and the levels of T lymphocyte subsets including CD3 + , CD4 + , CD8 + and CD4 +/CD8 + in peripheral blood were compared between the two groups. After treatment, the number of cases of decrease in leukocyte, platelet, and hemoglobin was compared between the two groups. Results: Compared with those before treatment in the same group, the scores of physical fatigue and general fatigue in CFS in the two groups were decreased(P<0.05),and the two scores in the treatment group were lower than those in the control group(P<0.05). Compared with those before treatment in the same group,the levels of CD3+,CD4+,and CD4+/CD8+ in the two groups were decreased(P<0.05),and the levels of CD8+ were increased(P<0.05). When compared with those in the control group after treatment,the levels of CD3+,CD4+,and CD4+/ CD8 + in the treatment group were increased(P<0.05),and the level of CD8 + as well as the cases of decrease in leukocyte was decreased(P<0.05). Conclusion:In the treatment of patients after surgery for colorectal cancer,Changyi jian assisting routine chemotherapy can effectively relieve their CRF and improve immune function,with lesser bone marrow suppression.

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张静.肠益煎辅助化疗对大肠癌术后癌因性疲乏、免疫功能影响的研究[J].新中医,2020,52(21):87-90

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  • 在线发布日期: 2020-11-05
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