中医辨证分型联合醋酸泼尼松治疗系统性红斑狼疮临床研究
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R293.24+1


Clinical Study of Chinese Medicine Syndrome Differentiation Combined with Predni⁃ sone Acetate for Systemic Lupus Erythematosus
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    摘要:

    目的:观察中医辨证分型用药联合醋酸泼尼松治疗系统性红斑狼疮(SLE) 的临床效果及对细胞因子的影响。方法:将SLE 患者120 例随机分为对照组与观察组,每组60 例。对照组给予醋酸泼尼松治疗,观察组在对照组的基础上联合中医辨证分型中药汤剂治疗,疗程均为6 个月,观察比较2 组临床疗效及不良反应,治疗前后血清细胞因子白细胞介素-16(IL-16)、白细胞介素-17(IL-17)、转化生长因子-β(TGF-β) 水平变化。结果:总有效率观察为83.33%,对照组为63.33%,2 组比较,差异有统计学意义(P<0.05)。治疗后,2 组患者血清IL-16、IL-17 水平较治疗前降低,TGF-β 水平升高,差异均有统计学意义(P<0.05);且观察组上述指标改善较对照组更显著(P<0.05)。不良反应发生率观察组为11.67%,对照组为16.67%,2 组比较,差异无统计学意义(P>0.05)。结论:中医辨证分型用药联合醋酸泼尼松治疗SLE 患者,可在不增加不良反应的同时提高疗效,改善血清细胞因子水平。

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    Abstract: Objective: To observe the clinical effect of Chinese medicine syndrome differentiation combined with prednisone acetate on systemic lupus erythematosus(SLE) and its influence on cytokines. Methods: A total of 120 SLE patients were randomly divided into the control group and the observation group,60 patients in each group. The control group was treated with prednisone acetate,and the observation group was treated with decoction according to Chinese medicine syndrome differentiation based on the treatment of the control group. Both groups were treated for six months. Before and after treatment,the clinical effect,the adverse reactions,the changes of levels of interleukin-16(IL-16),interleukin-17 (IL-17) and transforming growth factor- β(TGF-β) in serum in the two groups were observed and compared. Results:The total effective rate was 83.33% in the observation group and 63.33% in the control group,the difference being significant (P<0.05). After treatment, the levels of IL- 16 and IL- 17 in serum in both groups were decreased when compared with those before treatment,and TGF-β levels were increased,differences being significant(P<0.05),and the improvement of the above three indexes was better in the observation group than in the control group(P<0.05). The incidence of adverse reactions was 11.67% in the observation group and 16.67% in the control group,there being no significant difference(P> 0.05). Conclusion: TCM syndrome differentiation combined with prednisone acetate for SLE patients, can improve the curative effect and the levels of cytokines in serum,without increasing adverse reactions.

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王春芳,刘娟云.中医辨证分型联合醋酸泼尼松治疗系统性红斑狼疮临床研究[J].新中医,2020,52(21):81-83

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  • 在线发布日期: 2020-11-05
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