Abstract： Objective： To observe the clinical effect of Sihong Quban tang combined with hydroquinone cream for chloasma. Methods： A total of 82 cases of patients with chloasma were randomly divided into the control group and the observation group，41 cases in each group. The control group was treated with hydroquinone cream，and the observation group was additionally given oral administration of Sihong Quban tang based on the treatment of the control group. The changes in skin condition(water content and elasticity of skin)，and the levels of nitric oxide(NO) and superoxide dismutase (SOD) before and after treatment were compared between the two groups. The total clinical effect and the incidence of adverse reactions were counted in the two groups. Results：The total effective rate was 90.24% in the observation group， and 68.29% in the control group，the difference being significant(P＜0.05). After treatment，the water content and elasticity of skin in the two groups were increased when compared with those before treatment(P＜0.05)，and the improvement of the two indexes in the observation group was more significant than that in the control group(P＜0.05). After treatment，the levels of NO in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of SOD were increased(P＜0.05)； the improvement of above two indexes in the observation group was more significant than that in the control group(P＜0.05). The total incidence of adverse reactions was 3.64% in the observation group， and 20.00% in the control group，the difference being significant(P＜0.05). Conclusion：In the treatment of chloasma，the therapy of Sihong Quban tang combined with hydroquinone cream has better curative effect and safety than that of simple western medicine. It can effectively improve skin condition，slow down skin ageing，and keep the skin glowing.