清热化瘀方联合仿生物电刺激治疗宫腔粘连术后再粘连临床研究
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R711.4

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Clinical Study on Qingre Huayu Prescription Combined with Biomimetic Electrical Stimulation for Re-Adhesion After Surgery of Intrauterine Adhesion
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    摘要:

    目的:观察清热化瘀方联合仿生物电刺激治疗宫腔粘连术后再粘连的疗效。方法:选取90 例宫腔粘连术后再粘连患者,随机分为治疗组、观察组、对照组各30 例。对照组采用戊酸雌二醇片、黄体酮胶囊治疗,观察组采用戊酸雌二醇片、黄体酮胶囊+仿生物电刺激治疗,治疗组采用戊酸雌二醇片、黄体酮胶囊+仿生物电刺激+清热化瘀方治疗。比较3 组总有效率、月经恢复率、子宫内膜厚度,以及动脉血流情况、血清炎症因子水平、宫腔恢复情况、不良反应发生率。结果:总有效率治疗组为96.67%,观察组为73.33%,对照组为43.33%,治疗组总有效率高于观察组及对照组(P<0.05);观察组总有效率高于对照组(P<0.05)。月经恢复率治疗组为96.67%,观察组为70.00%,对照组为46.67%,治疗组高于观察组及对照组(P<0.05)。治疗后,3 组子宫内膜厚度均增加(P<0.05),子宫内膜螺旋动脉血流收缩末期峰值与舒张末期峰值比值(S/D)、搏动指数(PI)、阻力指数(RI) 均降低(P<0.05);治疗组子宫内膜厚度大于观察组及对照组(P<0.05),子宫内膜螺旋动脉S/D、PI、RI 低于观察组及对照组(P<0.05);观察组子宫内膜厚度大于对照组(P<0.05),子宫内膜螺旋动脉S/D、PI、RI 低于对照组(P<0.05)。治疗后,3 组白细胞介素(IL) -2、干扰素-γ (IFN-γ) 水平均降低(P<0.05),IL-4、IL-10 水平均升高(P<0.05);治疗组IL-2、IFN-γ 低于观察组及对照组(P<0.05),IL-4、IL-10 高于观察组及对照组(P<0.05);观察组IL-2、IFN-γ 低于对照组(P<0.05),IL-4、IL-10 高于对照组(P<0.05)。宫腔恢复正常率治疗组为63.33%,观察组为36.67%,对照组为10.00%,治疗组宫腔恢复正常率高于观察组及对照组(P<0.05)。不良反应发生率治疗组为3.33%,观察组为6.67%,对照组为13.33%,组间比较,差异无统计学意义(P>0.05)。结论:清热化瘀方联合仿生物电刺激治疗宫腔粘连术后再粘连疗效显著,可促进患者月经恢复与宫腔粘连的恢复,增加子宫内膜厚度,改善子宫内膜血流参数与机体免疫炎症反应。

    Abstract:

    Abstract: Objective: To observe the curative effect of Qingre Huayu prescription combined with biomimetic electrical stimulation for re-adhesion after surgery of intrauterine adhesion. Methods:A total of 90 cases of patients with re-adhesion after surgery of intrauterine adhesion were randomly divided into the treatment group, the observation group, and the control group,30 cases in each group. The control group was given estradiol valerate tablets and progesterone capsules;the observation group was given estradiol valerate tablets, progesterone capsules and biomimetic electrical stimulation; the treatment group was given estradiol valerate tablets,progesterone capsules,biomimetic electrical stimulation,and Qingre Huayu prescription. The total effective rate,menstruation recovery rate,and the thickness of endometrium were compared among the three groups. Artery blood flow,the levels of inflammatory factors in serum,the recovery of uterine cavity,and the incidence of adverse reactions were compared among the three groups. Results:The total effective rate was 96.67% in the treatment group, 73.33% in the observation group, and 43.33% in the control group; the total effective rate in the treatment group was higher than those in the observation group and the control group(P<0.05);the total effective rate in the observation group was higher than that in the control group(P<0.05). The rate of menstruation recovery was 96.67% in the treatment group,70.00% in the observation group,and 46.67% in the control group;the rate of menstruation recovery in the treatment group was higher than those in the observation group and the control group(P<0.05). After treatment, the thickness of endometrium in the three groups was increased(P<0.05); the ratio of peak end- systolic flow velocity to the peak end- diastolic flow velocity of endometrial spiral artery(S/D), pulsatility index(PI), and resistance index(RI) were decreased(P<0.05). After treatment, the thickness of endometrium in the treatment group was larger than that in the observation group and the control group(P<0.05);S/D,PI,and RI of endometrial spiral artery were lower than those in the observation group and the control group(P<0.05). After treatment,the thickness of endometrium in the observation group was larger than that in the control group(P<0.05);S/D,PI,and RI of endometrial spiral artery were lower than those in the control group(P<0.05). After treatment,the levels of interleukin- 2(IL-2) and interferon- γ(IFN-γ) in the three groups were decreased(P<0.05);the levels of IL-4 and IL-10 were increased(P<0.05). After treatment,the levels of IL-2 and IFN-γ in the treatment group were lower than those in the observation group and the control group(P<0.05);the levels of IL-4 and IL-10 were higher than those in the observation group and the control group(P<0.05). After treatment,the levels of IL-2 and IFN-γ in the observation group were lower than those in the control group(P<0.05);the levels of IL-4 and IL-10 were higher than those in the control group(P<0.05). The recovery rate of uterine cavity was 63.33% in the treatment group,36.67% in the observation group, and 10.00% in the control group; the recovery rate of uterine cavity in the treatment group was higher than those in the observation group and the control group(P<0.05). The incidence of adverse reactions was 3.33% in the treatment group,6.67% in the observation group,and 13.33% in the control group. No significant difference was found in the comparison of the incidence of adverse reactions among the three groups(P>0.05). Conclusion:In the treatment of re- adhesion after surgery of intrauterine adhesion, the therapy of Qingre Huayu prescription combined with biomimetic electrical stimulation has significant curative effect;the therapy can promote recovery of menstruation and from intrauterine adhesion,increase the thickness of endometrium,improve blood flow parameters of endometrium,and relieve immunoinflammatory response of body.

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高忆.清热化瘀方联合仿生物电刺激治疗宫腔粘连术后再粘连临床研究[J].新中医,2020,52(21):61-65

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  • 在线发布日期: 2020-11-05
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