Abstract： Objective： To observe the clinical effect of Qingli Shire prescription combined with amoxicillin clavulanate potassium tablets for chronic pelvic inflammation. Methods：A total of 142 cases of patients with chronic pelvic inflammation were selected and divided into the control group and the observation group according to the random number table method， 71 cases in each group. The control group was treated with amoxicillin clavulanate potassium tablets， and the observation group was additionally treated with Qingli Shire prescription based on the treatment of the control group. The clinical effect in the two groups was observed；the scores of Visual Analogue Scale(VAS) were evaluated；the levels of tumor necrosis factor-α (TNF-α)，interleukin-21(IL-21)，insulin-like growth factor 1(IGF-1)，superoxide dismutase(SOD)，glutathione peroxidase (GSH- Px) and malondialdehyde(MDA) were detected. Results： The total effective rate was 92.96% in the observation group，higher than that of 74.65% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of VAS scores between the two groups(P＞0.05). After treatment，average VAS scores in the two groups were decreased when compared with those before treatment，and VAS score in the observation group was lower than that in the control group， the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of TNF-α，IL-21，IGF-1，SOD， GSH-Px and MDA between the two groups(P＞0.05). After treatment，the levels of TNF-α，IL-21，IGF-1 and MDA in the two groups were decreased when compared with those before treatment， and the levels of SOD and GSH- Px were increased； the levels of TNF- α， IL- 21， IGF- 1 and MDA in the observation group were lower than those in the control group，and the levels of SOD and GSH-Px were higher，differences being significant(P＜0.05). Conclusion：The therapy of Qingli Shire prescription combined with amoxicillin clavulanate potassium tablets for chronic pelvic inflammation can reduce inflammatory responses，enhance antioxidant capacity and relieve pain.