Abstract：Objective：To observe the clinical effect of Longbishu capsules combined with doxazosin for benign prostatic hyperplasia(BPH). Methods： A total of 110 cases of BPH patients were randomly divided into the control group and the observation group， 55 cases in each group. The control group was given doxazosin mesylate tablets， and the observation group was additionally given the oral administration of Longbishu capsules based on the treatment of the control group. Before and after treatment， the changes in scores of International Prostate Symptom Score(IPSS) and quality of life(QOL)， maximum urinary flow rate(Qmax)，volume of postvoid residual urine，and the prostate volume were observed and compared in the two groups. The total clinical effect and the incidence of adverse reactions were counted in the two groups. Results： The total effective rate was 76.36% in the observation group， and 54.55% in the control group， the difference being significant(P＜0.05). After treatment， the scores of IPSS and QOL in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，and the Qmax was significantly increased when compared with that before treatment(P＜0.05)； the improvement of the indexes above in the observation group was more significant than that in the control group(P＜0.05). After treatment，the volume of postvoid residual urine and the prostate volume in the two groups was significantly decreased when compared with that before treatment(P＜0.05)；the improvement of the indexes above in the observation group was more significant than that in the control group(P＜0.05). The incidence of adverse reactions was 33.64% in the observation group，and 18.18% in the control group，the difference being significant(P＜0.05). Conclusion：In the treatment of BPH，the therapy of Longbishu capsules combined with doxazosin mesylate tablets can effectively narrow the prostate volume， relieve obstructive symptoms， reduce postvoid residual urine， and increase urinary flow rate， with lesser adverse reactions；its total curative effect is better than that of simple western medicine.