Abstract： Objective： To observe the clinical effect of Xiangdan injection combined with hormones for nephrotic syndrome. Methods： A total of 114 cases of patients with nephrotic syndrome were selected and divided into the control group and the observation group according to the random number table method，57 cases in each group. The control group was given hormones， and the observation group was additionally given Xiangdan injection based on the treatment of the control group. The Chinese medicine syndrome scores such as edema，the lumbar pain and fatigue were compared between the two groups；the contents of blood urea nitrogen(BUN)，serum creatinine(SCr) and 24-hour urine protein ratio as well as the levels of fibrinogen(FIB) and plasma viscosity(PV) were detected. The clinical effect and the incidence of adverse reactions were compared between the two groups. Results： Before treatment， when compared the scores of edema， the lumbar pain and fatigue between the two groups，there was no significance in the difference(P＞0.05). After treatment，the scores of edema， the lumbar pain and fatigue in the two groups were decreased when compared with those before treatment (P＜0.05)； the above three scores in the observation group were lower than those in the control group(P＜0.05). Before treatment，when compared the contents of BUN，SCr and 24- hour urine protein between the two groups，there was no significance in the difference(P＞0.05). After treatment， the contents of BUN， SCr and 24- hour urine protein in the two groups were decreased when compared with those before treatment(P＜0.05)；the above three contents in the observation group were lower than those in the control group(P＜0.05). Before treatment， when compared the levels of FIB and PV between the two groups，there was no significance in the difference(P＞0.05). After treatment，the levels of FIB and PV in the two groups were decreased when compared with those before treatment(P＜0.05)； the above two levels in the observation group were lower than those in the control group(P＜0.05). The total effective rate was 94.74% in the observation group， higher than that of 71.93% in the control group(P＜0.05). The incidence of adverse reactions was 7.02% in the observation group，lower than that of 33.33% in the control group(P＜0.05). Conclusion：The therapy of Xiangdan injection combined with hormones has significant curative effect in treating patients with nephrotic syndrome，which can improve the kidney function and hemorheology index，and reduce the incidence of adverse reactions.