Abstract： Objective： To observe the clinical effect of Haijing jian for premature ovarian failure(POF) with the kidney essence insufficiency syndrome. Methods： A total of 100 cases of patients were divided into two groups according to the random number table method， 50 cases in each group. Both groups were given compound estradiol valerate tablets and progesterone soft capsules； the control group was additionally given the oral administration of Liuwei Dihuang pills； the observation group was additionally given the oral administration of Haijing jian. Both groups were treated for three months. In the two groups， scores of menstruation， scores of Kupperman Index(KI) of clinical symptoms and the Chinese medicine syndrome scores of the kidney essence insufficiency before and after treatment were evaluated. In the two groups， the levels of estrogen(E2) and follicle stimulating hormone(FSH) in serum before and after treatment were tested. The clinical effect in the two groups was counted. Results：When compared the clinical effect between the two groups，the difference being significant(P＜0.05). The curative effect in the observation group was better than that in the control group. After treatment， the scores of menstruation， KI and the kidney essence insufficiency syndrome in the two groups were significantly decreased when compared with those before treatment(P＜0.01)；the above each score in the observation group was lower than that in the control group(P＜0.01). After treatment，the E2 levels in the two groups were significantly increased (P＜0.01)，and the FSH levels were significantly decreased(P＜0.01)；the improvement of the two indexes in the observation group was more significant than that in the control group(P＜0.01). Conclusion：Based on hormone replacement therapy，the additional oral administration of Haijing jian can improve menstruation of POF patients and the levels of sex hormones，relieve clinical symptoms and Chinese medicine syndrome，whose curative effect is better than that of Liuwei Dihuang pills.