Abstract：Objective：To discuss the clinical effect of Xiao'er Feike granules combined with azithromycin for mycoplasmal pneumonia in children and its effect on expression of related inflammatory factors. Methods：A total of 150 cases of children with mycoplasmal pneumonia were divided into the control group and the observation group according to the random number table method，75 cases in each group. The control group was given azithromycin，and the observation group was additionally treated with Xiao'er Feike granules based on the treatment of the control group. The difference of clinical effect，expression of inflammatory factors and complications between the two groups were compared. Results： The total effective rate was 88.0% in the control group and 97.3% in the observation group，the difference being significant(P＜0.05). After treatment， the levels of inflammatory factors in the two groups were improved when compared with those before treatment(P＜0.05)， and there was significance in the difference between the two groups(P＜0.05). During treatment，the incidence of adverse reactions was 14.7% in the control group and 4.0% in the observation group， the difference being significant(P＜0.05). Conclusion： Based on the treatment of azithromycin， the additional application of Xiao'er Feike granules can significantly improve clinical effect of mycoplasmal pneumonia in children，and reduce the expression of related inflammatory factors as well as the incidence of complications.