Abstract： Objective： To observe the curative effect of modified Liangge powder combined with routine western medicine for acute exacerbation of chronic obstructive pulmonary disease(AECOPD) of phlegm-heat obstructing the lung type complicated with acute gastrointestinal injury(AGI). Methods：A total of 64 cases of patients with AECOPD of phlegm- heat obstructing the lung and inhibited bowel qi type complicated with AGI were divided into the treatment group and the control group according to the random number table method，32 cases in each group. The control group was given routine western medicine，and the treatment group was additionally given the oral administration of decoction of modified Liangge powder for one dose per day based on the treatment of the control group. Both groups were treated for seven days. Before and after treatment， the syndrome scores of chronic obstructive pulmonary disease(COPD) and AGI， the times of bowel sound per minute，as well as the levels of peripheral white blood cell count(WBC)，C-reactive protein(CRP)，partial pressure of oxygen (PaO2)， partial pressure of carbon dioxide(PaCO2)， interleukin- 6(IL- 6)， tumor necrosis factor- α(TNF- α)， citrulline in serum，and intestinal fatty acid binding protein(IFABP) were compared between the two groups. Results：After treatment， the syndrome scores of COPD and AGI in the two groups were decreased when compared with those before treatment(P＜ 0.05)； after treatment， the two scores in the treatment group were lower than those in the control group(P＜0.05). The levels of WBC， CRP， PaCO2， IL- 6， TNF- α， and IFABP in the two groups were decreased when compared with those before treatment(P＜0.05)；after treatment，the six levels in the observation group were lower than those in the control group (P＜0.05). In the two groups， the times of bowel sound per minute， and the levels of PaO2 and citrulline were increased when compared with those before treatment(P＜0.05)； after treatment， the three indexes in the treatment group were higher than those in the control group(P＜0.05). Conclusion：The therapy of modified Liangge powder combined with routine western medicine can improve clinical symptoms and signs of patients with AECOPD of phlegm- heat obstructing the lung and inhibited bowel qi type complicated with AGI，relieve their inflammatory response，gastrointestinal injury，and the index of blood gas analysis.