Abstract： Objective： To observe the clinical effect of Shipi Yin combined with propranolol for ascites due to cirrhosis. Methods：A total of 74 cases of patients with ascites due to cirrhosis were randomly divided into two groups，37 cases in each group. The control group was treated with propranolol，and the observation group was additionally treated with Shipi yin based on the treatment of the control group. Both groups were continuously treated for one month. The clinical effect， abdominal circumference， the incidence of complications， as well as the levels of alanine aminotransferase(ALT) and aspartate aminotransferase(AST)， total bilirubin(TBil) and albumin(Alb) for evaluating the liver function were observed and compared between the two groups. Results：The total effective rate was 94.59% in the observation group and 75.68% in the control group，the difference being significant(P＜0.05). After treatment，the levels of ALT，AST and TBil in serum in the two groups were decreased when compared with those before treatment(P＜0.05)， and the levels of Alb were increased(P＜ 0.05)；the improvement of the above four indexes in the observation group was more significant than that in the control group (P＜0.05). After treatment，the abdominal circumference in the two groups was significantly decreased when compared with that before treatment(P＜0.05)， and the circumference in the observation group was significantly smaller than that in the control group(P＜0.05). The total incidence of ascites-related complications was 21.62% in the observation group and 37.84% in the control group， the difference being significant(P＜0.05). Conclusion： The therapy of Shipi Yin combined with propranolol in treating ascites due to cirrhosis can promote ascites disappearance，improve the liver function，and reduce the incidence of related complications.