Abstract：Objective：To observe the clinical effect of Xiaochaihu tang combined with low- dose levamlodipine besylate for chronic glomerulonephritis. Methods：A total of 124 cases of patients with chronic glomerulonephritis were selected and divided into the observation group and the control group，62 cases in each group. The control group was treated with routine treatment combined with low- dose levamlodipine besylate， and the observation group was additionally treated with Xiaochaihu tang based on the treatment of the control group. The clinical effect， the content of 24- hour urine protein， Chinese medicine symptom scores and the levels of inflammatory factors were compared between the two groups. Results： The total effective rate was 95.16% in the observation group， higher than that of 75.81% in the control group(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the content of 24-hour urine protein between the two groups(P＞0.05). After treatment，the contents of 24-hour urine protein in the two groups were decreased when compared with those before treatment(P＜0.05)，and the content in the observation group was lower than that in the control group(P＜0.05). Before treatment， compared the Chinese medicine symptom scores， namely dizziness and blur version，edema，nausea and vomiting，as well as torpid intake between the two groups，there was no significance in the difference(P＞0.05). After treatment，the four Chinese medicine symptom scores in the two groups were decreased when compared with those before treatment(P＜0.05)， and the scores in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of interleukin-17(IL-17) and interferon-γ(IFN-γ) in the two groups were decreased when compared with those before treatment，and the levels of interleukin-4(IL-4) were increased(P＜0.05)；the levels of IL- 17 and IFN- γ in the observation group were lower than those in the control group，and the level of IL- 4 was higher(P＜0.05). Conclusion： The therapy of Xiaochaihu tang combined with low- dose levamlodipine besylate has better clinical effect in treating chronic glomerulonephritis，and can reduce 24- hour urine protein and inflammatory response with safe medication.