Abstract：Objective：To observe the clinical effect of modified Huangqi Jianzhong tang combined with western medicine for stomachache of deficiency- cold of the spleen and stomach type. Methods： A total of 130 cases of patients with stomachache of deficiency- cold of the spleen and stomach type were selected as the study subjects and divided into the control group and the treatment group by the odd- even number grouping method according to the order of admission，65 case in each group. The control group was treated with amoxicillin，metronidazole and rebeprazole，and the treatment group was additionally treated with modified Huangqi Jianzhong tang based on the treatment of the control group. Both groups were treated for three months. The Chinese medicine syndrome scores， the levels of transforming growth factor- α(TGF- α)， epidermal growth factor(EGF)，interleukin- 17(IL- 17)，gastrin in serum and the levels of motilin in plasma before and after treatment as well as the clinical effect in the two groups were compared. The recurrence rates in the two groups were counted. Results：The total effective rate was 96.92% in the treatment group，higher than that of 87.69% in the control group (P＜0.05). After treatment， the scores of main symptoms， secondary symptoms as well as tongue and pulse in the treatment group were lower than those in the control group(P＜0.05). After treatment，the levels of TGF-α and EGF in serum as well as motilin in plasma in the treatment group were higher than those in the control group(P＜0.05)，and the levels of IL- 17 and gastrin in serum were lower than those in the control group(P＜0.05). After follow- up for six months， the recurrence rate was 1.59% in the treatment group and 14.04% in the control group，there being significance in the difference (P＜0.05). Conclusion：Modified Huangqi Jianzhong tang combined with western medicine for stomachache of deficiencycold of the spleen and stomach type can improve clinical symptoms，relieve inflammatory responses，promote recovery of gastric mucosa and reduce recurrence rates.