Abstract：Objective：To observe the effect of nursing of integrated Chinese and western medicine on immune factors and range of motion related to knee osteoarthritis. Methods：A total of 103 cases of patients with knee osteoarthritis were divided into two groups according to the random number table method， 51 and 52 cases in each group respectively. The control group was given routine western medicine nursing， and the observation group was given nursing of integrated Chinese and western medicine. Before and after nursing，the changes in levels of immune factors，pain scores，range of motion，the joint function，as well as quality of life were compared between the two groups. Results：After nursing，the levels of immune factors in the two groups were improved when compared with those before treatment(P＜0.05). After nursing， the levels of tumor necrosis factor- α(TNF- α)， interleukin- 6(IL- 6) and interleukin- 10(IL- 10) in the observation group were better than those in the control group，the difference being significant(P＜0.05). After nursing，pain scores in the two groups were decreased(P＜0.05). After nursing， the scores of the arthralgia and tenderness in the observation group were significantly lower than those in the control group，the difference being significant(P＜0.05). After nursing，the range of motion in knee， scores of knee function and quality of life in the two groups were improved when compared with those before treatment(P＜0.05). After nursing， the range of motion in knee， scores of knee function and quality of life in the observation group were significantly better than those in the control group， the difference being significant(P＜0.05). Conclusion： The application of nursing of integrated Chinese and western medicine can effectively improve the levels of immune factors in patients with knee osteoarthritis，relieve pain，and improve range of motion，knee function，as well as quality of life.