Abstract： Objective： To systematically evaluate the effectiveness and safety of the clinical effect of Chinese herbs of reinforcing healthy qi and eliminating pathogenic factors for patients with liver metastasis of colorectal cancer based on clinical thinking of modern Chinses medicine. Methods：The clinical randomized controlled trails(RCT) of liver metastasis of colorectal cancer treated with Chinese medicine prescription of reinforcing healthy qi and eliminating pathogenic factors were comprehensively collected.Two researchers independently selected literature，extracting data and evaluating the risk of bias. Then， Revman 5.3 software was used for Meta- analysis on recent clinical curative effect， Karnofsky performance status (KPS)， survival rate， carcinoembryonic antigen(CEA)， tumor marker 199(CA199)， alpha- fetoprotein(AFP)， alanine aminotransferase(ALT)， aspartate aminotransferase(AST) and the score of quality of life. Results： There were 10 literature included，involving 572 patients，271 in the control group(conventional treatment) and 301 in the treatment group(Chinese herbs of reinforcing healthy qi and eliminating pathogentic factors combined with conventional treatment).Compared with that in the control group，the treatment group had better effect on improving recent curative effect，KPS，ALT，AST and the score of quality of life，and decreasing CEA and CA199，differences being significant(P＜0.01). Conclusion：In the treatment of liver metastasis of colorectal cancer，Chinese herbs of reinforcing healthy qi and eliminating pathogenic factors based on clinical thinking of modern Chinese medicine can improve the recent clinical effect，physical strength，quality of life，and the liver function indexes including ALT and AST，and reduce tumor markers including CEA and CA199.