Abstract：Objective：To discuss the effect of extract of linderae aggregate leaf on pathology of the liver tissues and Toll- like receptor 4(TLR-4)/nuclear factor-κB(NF-κB) signaling pathway in the rat models with hyperlipidemia. Methods：A total of 40 cases of male rats of SPF level were randomly divided into the control group and the modeling group，10 and 30 rats in each group respectively. The rat models with hyperlipidemia were established through high- fat diet in the modeling group. After successful establishment，the rats in the modeling group were randomly divided into the model group and the linderae aggregate groups of high-dose and low-dose. The linderae aggregate groups of high-dose and low-dose were administered with gastric perfusion with extract of linderae aggregate leaf in 1.6 g/kg and 0.8 g/kg respectively，and the model group and the control group were given distilled water of same volume. After eight weeks of continuous medication， the changes in pathology of the liver tissues in rats were observed after HE staining，and the protein expression of TLR-4，NF-κB，tumor necrosis factor- α(TNF- α) and interleukin- 2(IL- 2) in their liver was detected by Western blot method. Results： When compared with that in the control group， in the model group， there was disorderly arrangement of the liver cells， inflammatory cell infiltration and lipid droplets of different sizes；the protein expression of TLR-4，NF-κB，TNF-α and IL-2 was increased(P＜0.05). When compared with those in the model group， in the groups of high- dose and low- dose， pathological morphology of the liver approached that in the control group； the arrangement of the liver cells was more orderly； inflammatory cell infiltration was significantly relieved； the number of small lipid droplets in the liver cells was decreased；cell vacuolization was significantly improved；the protein expression of TLR-4，NF-κB，TNF-α and IL-2 was decreased(P＜0.05)；the effect in the linderae aggregate group of high-dose was more significant. Conclusion：The extract of linderae aggregate leaf has significant improving effect on changes in pathology of the liver tissues in rat models with hyperlipidemia. Its mechanism is probably realized by blocking TLR- 4/NF- κB signaling pathway， and reducing protein expression of TNF-α and IL-2.