Abstract： Objective： To observe the effect of Qingre Lishi Huoxue prescription on levels of inflammatory factors， transforming growth factor β1(TGF-β1)，monocyte chemoattractant protein-1(MCP-1) and platelet derived growth factor-BB (PDGF-BB) in prostatic fluid in patients with chronic abacterial prostatitis(CAP). Methods：A total of 200 cases of CAP patients treated in urinary surgery of Huzhou Central Hospital from July 2016 to June 2018 were divided into the control group and the observation group according to the random number table method， 100 cases in each group. The control group was given 0.2 mg of tamsulosin hydrochloride sustained- release capsules once a day； the observation group was given self- made Qingre Lishi Huoxue prescription one dose in a day， which was taken once in the morning and once in the evening. Both groups were treated for one course. The levels of tumor necrosis factor-α(TNF-α)，interleukin-6(IL-6)，interleukin-8(IL-8)， TGF- β1，MCP- 1 and PDGF- BB in prostatic fluid，the Chinese medicine symptom scores and the NIH- Chronic Prostatitis Symptom Index(NIH- CPSI) before and after treatment， as well as the curative effect in the two groups were compared. Results：Compared with those in the same group before treatment，the scores of TNF-α，IL-6，IL-8，Chinese medicine symptoms and NIH-CPSI as well as the levels of TGF- β1，MCP-1 and PDGF-BB in prostatic fluid in the two groups were decreased after treatment(P＜0.05). After treatment，the levels of TNF-α，IL-6，IL-8，TGF-β1，MCP-1 and PDGF-BB in prostatic fluid and the scores of Chinese medicine symptoms and NIH-CPSI in the observation group were decreased when compared with those in the control group， differences being significant(P＜0.05). The effective rate was 90.00% in the observation group，higher than that of 78.00% in the control group(P＜0.05). Conclusion：Qingre Lishi Huoxue prescription can improve the Chinese medicine symptoms and clinical symptoms by reducing the levels of TNF-α，IL-6，IL-8，TGF-β1， MCP-1 and PDGF-BB in prostatic fluid of CAP patients，so as to achieve significant curative effect with good safety.