Abstract： Objective： To observe the clinical effect of Bushen Yifei Huaxian prescription for pulmonary fibrosis and its effect on the lung function and quality of life of patients. Methods：A total of 68 cases of patients with pulmonary fibrosis were randomly divided into the observation group and the control group，34 cases in each group. The control group was treated with prednisone， and the observation group was additionally treated with Bushen Yifei Huaxian prescription based on the treatment of the control group. After continuous treatment for three months，the clinical effect，as well as the changes in the indexes of the lung function including the forced expiratory volume in one second(FEV1) and the forced vital capacity(FVC)， and the scores of St. George's Respiratory Questionnaire(SGRQ) for the evaluation of quality of life before and after treatment were observed in the two groups. Results：The total clinical effective rate was 94.12% in the observation group and 73.53% in the control group，the difference being significant(P＜0.05). After treatment，the levels of FVC and FEV1 in the two groups were significantly increased(P＜0.05)；and the two levels in the observation group were significantly higher than those in the control group(P＜0.05). After treatment，the scores of impacts，activity and symptoms and the total score of SGRQ in the two groups were decreased when compared with those before treatment(P＜0.05)，and the above scores in the observation group were lower than those in the control group(P＜0.05). Conclusion： Bushen Yifei Huaxian prescription has significant curative effect in treating pulmonary fibrosis，which can effectively improve the lung function and quality of life of patients.