Abstract： Objective： To observe the clinical effect of Tongluo Ditan tang combined with rehabilitation training for shoulder-hand syndrome(SHS) after stroke. Methods：A total of 190 cases of SHS after stroke patients were divided into the control group and the observation group according to the random number table method，95 cases in each group. The control group was given routine medicine combined with rehabilitation training，and the observation group was additionally treated with Tongluo Ditan tang based on the treatment of the control group. Both groups were treated for four weeks. Before and after treatment， the changes in the scores of short- form Fugl- Meyer Assessment(FMA)， Visual Analogue Scale(VAS)， simplified Barthel index(BI)，SHS and Chinese medicine syndromes in the two groups were observed. The clinical effect in the two groups was compared. Results： After treatment， the scores of FMA and BI in the observation group were increased when compared with those before treatment， and the scores were higher than those in the control group； the scores of VAS， SHS and Chinese medicine syndromes in the observation group were decreased when compared with those before treatment， and the scores were lower than those in the control group， differences being significant(P＜0.05). The total effective rate was 92.63% in the observation group and 81.05% in the control group， the difference being significant(P＜ 0.05). Conclusion： The therapy of Tongluo Ditan tang combined with rehabilitation training in treating SHS after stroke can significantly relieve pain of the affected limb and improve upper limb function and activity of daily living.