Abstract： Objective： To observe the clinical effect of Chaihu Jia Longgu Muli tang combined with three needles for tremor in treating Parkinson disease(PD). Methods： A total of 68 cases of PD patients were selected and divided into the experiment group and the reference group according to the random number table method， 34 cases in each group. The reference group was given levodopa tablets， and the experiment group was given Chaihu Jia Longgu Muli tang combined with three needles for tremor. Both groups were treated for two months. The levels of glial fibrillary acidic protein(GFAP)， malondialdehyde(MDA) and superoxide dismutase(SOD) in serum in the two groups were detected. The Chinese medicine syndrome scores，cognitive function，motor function and clinical effect were compared between the two groups. Results： After treatment， the Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment，and the scores in the experiment group were lower than those in the reference group(P＜0.05). The total effective rate was 94.12% in the experiment group， higher than that of 73.53% in the reference group(P＜0.05). After treatment，in the two groups，the levels of GFAP and MDA in serum were decreased when compared with those before treatment(P＜0.05)，and the levels of SOD in serum were increased when compared with those before treatment(P＜0.05)； in the experiment group，the levels of GFAP and MDA in serum were lower than those in the reference group(P＜0.05)，and the level of SOD in serum was higher than that in the reference group(P＜0.05). After treatment，the scores of Mini-Mental State Examination(MMSE) in the two groups were increased when compared with those before treatment(P＜0.05)，and the score in the experiment group was higher than that in the reference group(P＜0.05)； the scores of Alzheimer's Disease Assessment Scale- Cognitive section(ADAS- cog) ， Unified Parkinson Disease Rating Scale(UPDRS- Ⅲ) and Functional Activities Questionnaire(FAQ) in the two groups were decreased when compared with those before treatment(P＜0.05)，and the three scores in the experiment group were lower than those in the reference group(P＜0.05). Conclusion：The therapy of Chaihu Jia Longgu Muli tang combined with three needles for tremor can effectively regulate the levels of GFAP，SOD and MDA in serum，improve the clinical symptoms，and conduce to recovering cognitive and motor function.