Abstract： Objective： To observe the preventive effect of moxibustion based on integrated prevention and nursing on deep venous thrombosis(DVT) in patients with tumor. Methods： A total of 80 cases of patients with tumor were randomly divided into the control group and the observation group， 40 cases in each group. Both groups were given integrated prevention and nursing measures such as compression stockings， raising the lower limbs， massage， diet nursing and medicine， and the observation group was additionally treated with moxibustion at Yongquan(KI1) and Zusanli(ST36). Both groups were observed for 14 days. Every day， the symptoms including pain， swelling and numbness of limbs， and the changes in the skin color and temperature of lower limbs were inspected； the incidence of DVT in the two groups was calculated. Before and after treatment，the blood flow velocity and perimeter of lower limbs were measured；the levels of fibrinogen(FIB) and D- dimer(D- D) were detected. Results： The incidence of swelling pain， numbness and blood flow slowing down in the observation group was lower than that in the control group，differences being significant(P＜0.05)；the incidence of DVT and skin color changing was lower than that in the control group，but there was no significance in differences (P＞0.05). The blood flow velocity of lower limbs in the two groups was slowed down when compared with that before treatment(P＜0.05)， and the perimeter of lower limbs was increased when compared with that before treatment(P＜0.05). The blood flow velocity of lower limbs in the observation group was faster than that in the control group(P＜0.05)，and the perimeter of lower limbs was smaller than that in the control group(P＜0.05). The levels of FIB and D- D in the two groups were decreased when compared with those before treatment(P＜0.01)，and the above two levels in the observation group were lower than those in the control group(P＜0.01). Conclusion：The additional application of moxibustion at Yongquan(KI1) and Zusanli(ST36) based on integrated prevention and nursing can effectively promote the blood circulation in patients with tumor，reduce the risk of DVT.