Abstract：Objective：To observe the clinical effect of Taoren Xikang pills combined with glucosamine hydrochloride for chondromalacia patella. Methods：A total of 60 cases of patients with chondromalacia patella were randomly divided into two groups， 30 cases in each group. The control group was given glucosamine hydrochloride， and the observation group was additionally given Taoren Xikang pills based on the treatment of the control group. The scores of VAS，the circumferences of muscle，Q angle，the degree of pain in anterior knee during squatting，the knee society scores(KSS) as well as the excellent and good rate of knee flexion in the two groups were observed and compared between the two groups. Results： After treatment， the excellent and good rate of knee flexion was 96.66% in the observation group and 73.33% in the control group，the difference among the groups being significant(P＜0.05). After treatment，the scores of VAS，the circumferences of muscle and Q angle in the two groups were significantly decreased when compared with those before treatment(P＜0.05)； the above indexes in the observation group were significantly lower than those in the control group(P＜0.05). When compared the degree of pain in anterior knee and the KSS in the two groups before treatment with those on the 1st week of treatment， there was no significance in the difference(P＞0.05). On the 5th week of treatment，the score of pain in anterior knee in the observation group was significantly lower than that in the control group，and the KSS was significantly higher than that in the control group， differences being significant(P＜0.05). Conclusion： The therapy of Taoren Xikang pills combined with glucosamine hydrochloride in treating chondromalacia patella，can effectively alleviate the pain in limbs of patients，improve activity ability，strengthen muscular tension as well as recover the knee function，whose curative effect is better than that of simple western medicine.