Abstract：Objective：To analyze the diagnostic value of musculoskeletal ultrasound on the evaluation of cartilage injury in patients with knee osteoarthritis of liver-kidney deficiency type. Methods：The results of ultrasonic and magnetic resonance imaging(MRI) of knee joint before joint replacement in 172 patients with knee osteoarthritis of liver- kidney deficiency type were retrospectively analyzed， and the analytical results were compared with the cartilage damage of femoral trochlear， medial condyle and lateral condyle appeared in the operation. Then the sonographic characteristics of ultrasonic diagnosis of cartilage injury was analyze and the diagnostic coincidence rate and diagnostic efficacy of ultrasonic diagnosis of knee musculobone and MRI were compared. Results： The ultrasonic manifestations of knee joint in patients with knee osteoarthritis of liver-kidney deficiency type not only showed the lesion of synovitis，but also the obvious lesions of medial and lateral cartilage of the femoral trochlear，mainly including unclear layers of cartilage，obviously thinned and missing local cartilage，and rough subchondral surface. The diagnostic coincidence rate was 90.70% in the MRI group and 84.30% in the musculoskeletal ultrasound group， there being no significant difference(P＞0.05). ROC curve showed that the diagnosis efficiency of musculoskeletal ultrasound in the diagnosis of knee cartilage injury was high，which was consistent with that of MRI. Conclusion： Musculoskeletal ultrasound is of high value in diagnosing knee osteoarthritis and evaluating articular cartilage injury， with low cost and no contraband， which can be used as an important method for grading treatment and effect evaluation of knee osteoarthritis，especially in primary hospitals lacking MRI equipment.