Abstract： Objective： To observe the clinical effect of Gukang capsules combined with etoricoxib tablets for knee osteoarthritis and its effect on inflammatory factors and hemorheology. Methods：A total of 100 cases of patients with knee osteoarthritis were divided into the control group and the observation group according to different therapeutic schemes，48 and 52 cases in each group respectively. The control group was treated with etoricoxib tablets，and the observation group was additionally treated with Gukang capsules based on the treatment of the control group. Both groups were treated for four weeks. The levels of inflammatory factors and hemorheology indexes before and after treatment and the clinical effect in the two groups were compared； the incidence of adverse reactions was recorded. Results： After treatment， the levels of interleukin-1β(IL-1β)，interleukin-6(IL-6)，tumor necrosis factor-α(TNF-α)，prostaglandin E2(PGE2) and matrix metalloproteinase- 13(MMP- 13) in the two groups were decreased when compared with those before treatment(P＜0.05)， and the above levels in the observation group were lower than those in the control group(P＜0.05). After treatment，the levels of whole blood viscosity at low shear and high shear，plasma viscosity and erythrocyte aggregation index in the two groups were decreased when compared with those before treatment(P＜0.05)，and the levels of erythrocyte deformation index were increased(P＜0.05)； the levels of whole blood viscosity at low shear and high shear， plasma viscosity and erythrocyte aggregation index in the observation group were lower than those in the control group(P＜0.05)，and the level of erythrocyte deformation index was higher(P＜0.05). The total effective rate was 94.23% in the observation group， higher than that of 66.67% in the control group(P＜0.05). The incidence of adverse reactions was 9.62% in the observation group and 6.25% in the control group，there being no significance in the difference(P＞0.05). Conclusion：Gukang capsules for patients with knee osteoarthritis can improve inflammatory responses，blood circulation and curative effect，with good medication safety.