Abstract：Objective：To observe the clinical effect of extract of Folium Ginkgo combined with citicoline sodium tablets for acute cerebral hemorrhage. Methods：A total of 72 cases of patients with acute cerebral hemorrhage were randomly divided into two groups，36 cases in each group. The control group was treated with citicoline sodium tablets，and the treatment group was additionally treated with extract of Folium Ginkgo based on the treatment of the control group. The clinical effect and the changes of volume of cerebral hematoma as well as cerebral edema，scores of National Institutes of Health Stroke Scale(NIHSS) as well as Activities of Daily Living(ADL)，and levels of matrix metalloproteinase- 9(MMP-9)，S-100β protein and neuron-specific enolase(NSE) before and after treatment in the two groups were observed and compared；the incidence of adverse reactions was counted. Results：The total effective rate was 91.67% in the treatment group and 63.89% in the control group， the difference being significant(P＜0.05). After treatment， the volumes of cerebral hematoma in the two groups tended to decrease；on the 14th day after treatment，the volume in the treatment group was significantly smaller than that in the control group(P＜0.05). After treatment，the volumes of cerebral edema in the two groups were decreased when compared with those before treatment；on the 7th and 14th day after treatment respectively，the volume of cerebral edema in the treatment group was significantly smaller than that in the control group respectively(P＜0.05). After treatment，the scores of NHISS in the two groups were significantly decreased when compared with those before treatment(P＜0.05)，the scores of ADL were significantly increased(P＜0.05)；the improvement of the above two scores in the treatment group was superior to that in the control group(P＜0.05). After treatment，the levels of MMP-9 in the two groups showed a downward trend；on the 7th and 14th day after treatment respectively，the above level in the treatment group was significantly lower than that in the control group(P＜0.05). On the 3rd and 7th day after treatment respectively， the levels of S- 100β in the two groups were increased when compared with those before treatment(P＜0.05)，and the level in the treatment group was lower than that in the control group(P＜0.05)；on the 14th day after treatment，the levels of S- 100β in the two groups were decreased when compared with those before treatment(P＜0.05)， and the level in the treatment group was slightly lower than that in the control group，but there being no significant in the difference(P＞0.05). After treatment，the levels of NSE in the two groups showed a downward trend，and on the 3rd and 7th day after treatment，the level in the treatment group was lower than that in the control group(P＜0.05). No obvious adverse reaction was found in the two groups in the treatment. Conclusion： The therapy of extract of Folium Ginkgo combined with citicoline sodium tablets in treating acute cerebral hemorrhage has good clinical effect， which can reduce levels of MMP- 9， S- 100β and NSE in serum， relieve cerebral edema and improve neurologic impairment and activities of daily living of patients.