Abstract： Objective： To observe the clinical effect of comprehensive nursing of Chinese medicine for patients with gastrointestinal dysfunction of severe sepsis. Methods： A total of 78 cases of patients with gastrointestinal dysfunction of severe sepsis were randomly divided into two groups，39 cases in each group. The control group was given routine nursing， and the observation group was given comprehensive nursing of Chinese medicine. Before and after intervention，the scores of Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ)， gastrointestinal dysfunction and bowel sounds， the abdominal pressure，the pH values of gastrointestinal mucosa and the levels of D-lactate in plasma in the two groups were observed and compared. After intervention， the first defecation time， the recovery time of bowel sounds， the gastric retention and the mortality in the two groups were compared. Results： After intervention， the scores of APACHE Ⅱ ， gastrointestinal dysfunction and bowel sounds in the two groups were significantly decreased when compared with those before intervention(P＜0.05)；the above scores in the observation group were lower than those in the control group(P＜0.05). After intervention， the abdominal pressure and the levels of D- lactate in plasma in the two groups were significantly decreased when compared with those before intervention(P＜0.05)， and the pH value of gastrointestinal mucosa was significantly increased(P＜0.05)；the improvement of the above indexes in the observation group was more significant than that in the control group(P＜0.05). After intervention，the first defecation time and the recovery time of bowel sounds in the observation group were shorter than those in the control group，and the incidence of gastric retention and the mortality were lower，differences being significant(P＜0.05). Conclusion：The intervention of comprehensive nursing of Chinese medicine hassignificant effect in treatingpatients with gastrointestinal dysfunction of sepsis， which can effectively improve gastrointestinal function，promote the recovery of gut barrier and reduceincidence of gastric retention and mortality.