Abstract： Objective： To observe the clinical effect of point application with Chinese herbal medicine combined with nursing guidance for primary insomnia in senile patients. Methods： A total of 134 cases of senile patients with primary insomnia were divided into the control group and the observation group according to the random number table method，66 and 68 cases in each group respectively. Both groups were given the oral administration of zopiclone tablets and nursing guidance measures including suggestion therapy of behavior psychology；the control group was additionally treated with farinfrared magnetic therapy patch，and the observation group was additionally treated with point application with Chinese herbal medicine. The scores of Pittsburgh Sleep Quality Index(PSQI)，Self-rating Depression Scale(SDS)，Self-rating Anxiety Scale (SAS) and Fatigue Scale- 14(FS- 14) before and after treatment in the two groups were compared. The parameters of sleep latency(SL)， arousal times(AT)， sleep efficiency(SE) and the total sleep time(TST) were recorded by polysomnography. Results：The clinical effect in the observation group was better than that in the control group，the difference being significant (Z=2.237，P＜0.05). After treatment，the scores of PSQI，SDS and SAS in the two groups were decreased when compared with those before treatment，and the above scores in the observation group were all lower than those in the control group， differences being significant(P＜0.05). After treatment，the total scores of physical fatigue，mental fatigue and FS-14 in the two groups were lower than those before treatment，and the above scores in the observation group were lower than those in the control group， differences being significant(P＜0.05). After treatment， SL and AT in the two groups were decreased when compared with those before treatment，and SE and TST were increased；SL and AT in the observation group were lower than those in the control group， and SE and TST were higher； there was significance in differences(P＜0.05).Conclusion：Point application with Chinese herbal medicine can significantly improve the sleep quality of patients，prolong their sleep time，and relieve their depression，anxiety and fatigue caused by sleep，which has good clinical effect.