Abstract：Objective：To observe the clinical effect of Gengnian'an capsules for climacteric syndrome. Methods：A total of 60 cases of patients with climacteric syndrome were randomly divided into the control group and the observation group， 30 cases in each group. The control group was treated with tibolone tablets， and the observation group was additionally treated with Gengnian'an capsules based on the treatment of the control group. Both groups were treated for three courses，one menstrual cycle being a course. The clinical effect and the changes of levels of sex hormones before and after treatment in the two groups were observed. Results：The total effective rate was 96.67% in the observation group and 73.33% in the control group，the difference being significant(P＜0.05). After treatment，the levels of E2 in serum in the two groups were increased when compared with those before treatment(P＜0.05)，and the levels of FSH and LH were decreased(P＜0.05)； the improvement of the above three levels in the observation group was more obvious than that in the control group(P＜0.05). Conclusion： Gengnian'an capsules for climacteric syndrome has definite clinical effect and can effectively improve clinical symptoms and levels of sex hormones.