活血养阴汤治疗早期糖尿病肾病临床研究
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R587.1;R692

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Clinical Study on Huoxue Yangyin Tang for Early Diabetic Nephropathy
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    摘要:

    目的:观察活血养阴汤治疗早期糖尿病肾病的临床疗效。方法:选取早期糖尿病肾病患者110例,按随机数字表法分为对照组和观察组各55例。2组均给予常规糖尿病治疗,对照组同时给予马来酸依那普利片口服,观察组在对照组基础上加用活血养阴汤治疗。比较2组患者治疗前后血尿酸(UA)、血β2-微球蛋白(β2-MG)、血肌酐(SCr)、尿素氮(BUN)、尿蛋白排泄率(UAER) 水平、中医证候积分,记录疗效和不良反应。结果:观察组总有效率为85.45%,高于对照组63.64%,差异有统计学意义(P<0.05)。治疗后,2组UA、SCr、UAER水平低于治疗前,且观察组UA、SCr、UAER、β2-MG水平低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组中医证候积分较治疗前降低,且观察组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。结论:采用活血养阴汤治疗早期糖尿病肾病患者,能够有效改善患者肾功能,缓解临床症状,不良反应少。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Huoxue Yangyin tang for early diabetic nephropathy. Methods:A total of 110 cases of patients with early diabetic nephropathy were selected and divided into the control group and the observation group according to the random number table method,55 cases in each group. Both groups were given routine diabetic treatment. Meanwhile,the control group was given the oral administration of enalapril maleate,and the observation group was additionally treated with Huoxue Yangyin tang based on the treatment of the control group. Before and after treatment,the levels of serum uric acid(UA),serum β2-microglobulin(β2-MG),serum creatinine(SCr),blood urea nitrogen (BUN),urinary albumin excretion rate(UAER) and Chinese medicine syndrome scores in the two groups were compared. The curative effect and adverse reactions were recorded. Results:The total effective rate was 85.45% in the observation group, higher than that of 63.64% in the control group,the difference being significant(P<0.05). After treatment,the levels of UA, SCr and UAER in the two groups were lower than those before treatment,and the levels of UA,SCr,UAER and β2-MG in the observation group were lower than those in the control group, differences being significant(P<0.05). After treatment, Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the observation group was lower than that in the control group,differences being significant(P<0.05). Conclusion: The application of Huoxue Yangyin tang for patients with early diabetic nephropathy can effectively improve their kidney function and relieve the clinical symptoms with few adverse reactions.

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潘丹丹.活血养阴汤治疗早期糖尿病肾病临床研究[J].新中医,2020,52(12):76-78

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  • 在线发布日期: 2020-06-15
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