扶正抗痨汤联合化疗治疗复治肺结核临床研究
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R521.1

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Clinical Study on Fuzheng Kanglao Tang Combined with Chemotherapy for Retreat⁃ ment Pulmonary Tuberculosis
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    摘要:

    目的:观察扶正抗痨汤联合化疗治疗复治肺结核的临床疗效。方法:将78例复治肺结核患者随机分为对照组39例与治疗组39例,对照组给予复治肺结核方案2HREZS/6HRE或者3HREZ/6HRE(链霉素不耐受者) 治疗,治疗组在对照组的基础上联合扶正抗痨汤治疗;观察比较2 组临床疗效、痰检阴转率、病灶吸收率、空洞闭合率及免疫功能(CD4+、CD8+、CD4+/CD8+) 变化情况。结果:总有效率治疗组为94.87%,对照组为79.49%,2 组比较,差异有统计学意义(P<0.05)。治疗组痰检阴转率、病灶吸收率、空洞闭合率分别为100.00%、92.31%、87.50%,对照组分别为77.78%、74.36%、53.33%,2组比较,差异均有统计学意义(P<0.05)。治疗后,治疗组患者CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组,组间比较,差异均有统计学意义(P<0.05)。结论:扶正抗痨汤联合西药化疗治疗复治肺结核疗效显著,可明显提高患者痰检阴转率、病灶吸收率及空洞闭合率,并可改善患者的免疫功能,值得临床推广应用。

    Abstract:

    Abstract: Objective: To observe the clinical effect of Fuzheng Kanglao tang combined with chemotherapy for retreatment pulmonary tuberculosis. Methods:A total of 78 cases of patients with retreatment pulmonary tuberculosis were randomly divided into the control group and the treatment group, 39 cases in each group. The control group was given 2HREZS/6HRE regimen of retreatment pulmonary tuberculosis or 3HREZ/6HRE chemotherapeutic regimen for patients with streptomycin intolerance, and the treatment group was additionally given Fuzheng Kanglao tang. The clinical effect, the negative conversion rate of sputum examination,the absorption rate of lesions,the closure rate of cavity,and the changes in the levels of immune function including CD4 + , CD8 + and CD4 +/CD8 + in the two groups were observed and compared. Results:The total effective rate was 94.87% in the treatment group and 79.49% in the control group,the difference being significant(P<0.05). The negative conversion rate of sputum examination,the absorption rate of lesions,and the closure rate of cavity in the treatment group were 100.00%,92.31% and 87.50% respectively;the above three rates in the control group were 77.78%,74.36% and 53.33% respectively;differences were significant(P<0.05). After treatment,the levels of CD4+ and CD4+/CD8+ in the treatment group were higher than those in the control group,and the level of CD8+ was lower than that in the control group,differences being significant(P<0.05). Conclusion:The therapy of Fuzheng Kanglao tang combined with chemotherapy of western medicine has significant curative effect in treating retreatment pulmonary tuberculosis,which can significantly increase the negative conversion rate of sputum examination and the absorption rate of lesions,as well as the closure rate of cavity of patients,and improve immune function of patients. It is worthy of clinical promotion and application.

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余心琦,陈道挺.扶正抗痨汤联合化疗治疗复治肺结核临床研究[J].新中医,2020,52(12):67-69

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  • 在线发布日期: 2020-06-15
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