Abstract：Objective：To observe the clinical effect of modified Chaishao Liujunzi tang and Gexia Zhuyu tang combined with routine therapy of modern medicine for chronic pancreatitis(CP). Methods： A total of 90 cases of CP patients after surgery were randomly divided into the control group and the observation group，45 cases in each group. After endoscopic therapy，both groups were treated with pancreatin enteric- coated capsules and omeprazole enteric- coated capsules，and paracetamol and tramadol hydrochloride tablets if the pain can not be controlled. The observation group was additionally treated with oral administration of modified Chaishao Liujiunzi tang and Gexia Zhuyu tang. Both groups were treated for eight weeks. The postoperative pain[Visual Anglogue Scale(VAS)] and the use of paracetamol and tramadol hydrochloride tablets in the two groups were evaluated； the Chinese medicine syndrome scores and the scores of Gastrointestinal Quality of Life Index(GIQLI) before and after treatment，as well as the Coefficient of Fat Absorption(CFA) after treatment were evaluated； the curative effect on Chinese medicine syndromes was compared between the two groups. Results：After treatment，the curative effect of Chinese medicine syndromes in the observation group was better than that in the control group(P＜0.05). The VAS scores on the 3rd，5th and 7th day of treatment showed a gradual downward trend in the two groups(P＜0.01)，and the above scores in the observation group were all lower than those in the control group(P＜0.01). The Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P＜0.01)，and the GIQLI scores were increased(P＜0.01). The Chinese medicine syndrome scores in the observation group were lower than those in the control group(P＜0.01)，and the GIQLI score was higher(P＜0.01). The usage of paracetamol and tramadol hydrochloride tablets in the observation group was less than that in the control group， and the CFA was higher than that in the control group，differences being significant(P＜0.01). Conclusion：Based on routine postoperative therapy，the therapy of modified Chaishao Liujunzi tang and Gexiao Zhuyu tang has good clinical effect in treating CP patients，which can effectively relieve abdominal pain and reduce the usage of paracetamol and tramadol hydrochloride tablets in a short term， and effectively improve clinical symptoms，fat absorption，pancreatic secretion function and quality of life in a long term.