Abstract：Objective：To discuss the application value of accelerated rehabilitative care of integrated Chinese and western medicine on patients after laparoscopic cholecystectomy(LC) at perioperative period. Methods： A total of 268 cases of patients after LC were randomly divided into the control group and the observation group， 134 cases in each group. Both groups were given intravenous combined anesthesia and LC by routine four-hole method. At perioperative period，the control group was given routine nursing invention，and the observation group was given accelerated rehabilitative care of integrated Chinese and western medicine. After operation，the operation time，the off- bed time，the exhaust time，the defecation time，the hospitalization time，the hospitalization expenses，the pain score at postoperative 24 hours，the self-care ability at postoperative 48 hours and the incidence of complications in the two groups were compared. Results：After treatment， the operation time， the off- bed time as well as the exhaust time， the defecation time and the hospitalization time after operation in the observation group were shorter than those in the control group，and the hospitalization expense was less，differences being significant(P＜0.05). After treatment，the pain score at postoperative 24 hours in the observation group was significantly lower than that in the control group，and the score of self-care ability at postoperative 48 hours was significantly higher than that in the control group，differences being significant(P＜0.05). The incidence of complications was 12.69% in the observation group and 41.79% in the control group， the difference being significant(P＜0.05). Conclusion： The accelerated rehabilitative care of integrated Chinese and western medicine for patients after LC at perioperative period can significantly relieve postoperative pain，improve self-care ability，reduce complications and effectively promote postoperative rehabilitation，so as to reduce medical costs.