Abstract： Objective： To observe the effect of the therapy of aerosol inhalation of Xiao'er Pingchuan prescription combined with salbutamol sulphate aerosol on acute attack of bronchial asthma. Methods： A total of 96 children with syndrome of wind-cold fettering the lung were randomly divided into the observation group and the control group，48 cases in each group. Both groups were treated with salbutamol sulphate aerosol and given guidance on the nursing measures of aerosol inhalation. The observation group was additionally treated with aerosol inhalation of Xiao'er Pingchuan prescription.Both groups were treated for seven days. Four weeks after the treatment course， Children's Asthma Control test(C- ACT) was performed in both groups；the Peak Expiratory Flow(PEF) was recorded three times a day，and the PEF fluctuation was counted； the severity score of acute asthma was assessed before and after treatment. The clinical effect and nursing satisfaction were compared between the two groups. Results：After treatment，the curative effect and asthma control in the observation group were better than those in the control group(P＜0.05). The day- night volatility of PEF in both groups was lower than that before treatment respectively(P＜0.01)， and the severity score of acute asthma attack in both groups was decreased when compared with that before treatment respectively(P＜0.01). The day-night volatility of PEF in the observation group was lower than that in the control group(P＜0.01)，and the severity score of acute asthma attack was lower than that in the control group as well(P＜0.01). The nursing satisfaction in the observation group was higher than that in the control group (P＜0.05). Conclusion：The additional application of aerosol inhalation of Xiao'er Pingchuan prescription based on salbutamol sulphate aerosol，can reduce the severity of asthma，control its attack and improve lung function.