Abstract： Objective： To investigate the clinical effect of Jianpi Huaji prescription for patients with advanced gastric cancer undergoing chemotherapy. Methods：A total of 76 cases of patients with advanced gastric cancer were divided into the control group and the study group according to the random number table method，38 cases in each group. The control group was given standard chemotherapy regimen and chemotherapy- related adjuvant therapy， and the study group was additionally treated with Jianpi Huaji prescription based on the treatment of the control group. After two cycles of chemotherapy，the changes in the size of tumor，tumor markers，body mass index，clinical symptoms and quality of life in the two groups were observed. Results：The total effective rate was 83.33% in the study group，higher than that of 44.12% in the control group，the difference being significant(P＜0.05). Before treatment，there was no significant difference being found in the comparison of the levels of carcinoembryonic antigen(CEA)，CA125，CA199 and CA724 between the two groups (P＞0.05). After treatment， the levels of CEA， CA125， CA199 and CA724 in the study group were decreased when compared with those before treatment(P＜0.05)， and the levels of CEA， CA125 and CA199 in the control group were decreased when compared with those before treatment(P＜0.05). Before treatment， there was no significant difference being found in the comparison of the values of body mass index(BMI) between the two groups(P＞0.05). After treatment，the value of BMI in the study group was increased when compared with that before treatment and it was higher than that in the control group， differences being significant(P＜0.05). After treatment， the scores of Quality of Life Scale(QOL) in the two groups were increased when compared with those before treatment，and the above score in the study group was higher than that in the control group，differences being significant(P＜0.05). Conclusion：Jianpi Huaji prescription can effectively improve the clinical symptoms and quality of life of patients with advanced gastric cancer undergoing chemotherapy，which has safe and reliable clinical application and can be used as their adjuvant medicines.