Abstract：Chronic urticaria(CU) is a common skin disease with complex etiology，characterized by recurrent episodes， and is difficult to be treated requiring a long recovery time. Western medicine treatment is usually symptomatic，but the rash is easy to relapse after withdrawal of medicine，seriously affecting the quality of life of patients. Acupuncture and moxibustion has a certain advantage in treating this disease with significant therapeutic effect. By referring to the literatures on the methods and mechanisms of acupuncture and moxibustion in treating CU in recent years，after summarized and analyzed， the mechanism and clinical application of comprehensive therapy of acupuncture and moxibustion in treating CU were reviewed，so as to provide reference for its further research and development.