Abstract：Objective：To observe the clinical effect of Yixuesheng capsules combined with DA chemotherapy regimen for acute myeloid leukemia(AML). Methods：A total of 140 cases of AML patients were divided into two groups according to the random number table method， 70 cases in each group. Both groups were given supportive treatments such as stopping vomiting，protecting the stomach，and hydration；the control group was given routine DA chemotherapy regimen including daunorubicin and cytarabine； the observation group was additionally treated with Yixuesheng capsules based on the treatment of the control group. Both groups were treated for 21 days. Before treatment as well as on the 7th，14th and 21st days of treatment， white blood cell count， platelet count and the hemoglobin level as well as the incidence of toxic side effects during treatment were compared between the two groups. Results：On the 7th，14th and 21st days of treatment，the levels of white blood cells，platelets and hemoglobin in the two groups were decreased when compared with those before treatment，the difference being significant(P＜0.05)；the above three levels in the observation group were higher than those in the control group at the same period， the difference being significant(P＜0.05). The severity of leukopenia and thrombocytopenia in the observation group was lower than that in the control group the difference being significant(P＜ 0.05)； when compared decreased hemoglobin， gastrointestinal responses and the liver impairment between the two groups， there was no significance in differences(P＞0.05). Conclusion： AML patients treated with Yixuesheng capsules with DA chemotherapy regimen can significantly improve the levels of routine blood indexes，and reduce the severity of myelosuppression.