健脾疏肝法治疗2型糖尿病合并冠心病临床研究
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R541.4;R587.1

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珠海市科技计划项目(20161027E030058)


Clinical Study on Jianpi Shugan Method for Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease
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    摘要:

    目的:观察健脾消糖颗粒治疗2 型糖尿病合并冠心病的临床疗效。方法:将64 例2 型糖尿病合并冠心病患者按随机数字表法分为观察组31 例和对照组33 例。对照组给予常规治疗,观察组在对照组基础上加用健脾消糖颗粒。观察2 组治疗前后核转录因子(NF-κB) 活性、空腹血糖(FBG)、餐后2 h 血糖(P2hBG) 及中医证候积分的变化。结果:治疗前,2 组FBG、P2hBG 水平比较,差异无统计学意义(P>0.05)。治疗后,2 组FBG、P2hBG 水平较治疗前降低,且观察组FBG、P2hBG 水平低于对照组,差异均有统计学意义(P<0.05)。治疗前,2 组NF-κB 活性及中医证候积分比较,差异无统计学意义(P>0.05)。治疗后,2 组NF-κB 活性及中医证候积分较治疗前降低,且观察组NF-κB 活性及中医证候积分低于对照组,差异均有统计学意义(P<0.05)。结论:健脾消糖颗粒能抑制2 型糖尿病合并冠心病患者NF-κB 的活性,减轻炎症反应,降低FBG、P2hBG 水平,改善患者的临床症状,疗效较好。

    Abstract:

    Abstract:Objective:To observe the clinical effect of Jianpi Xiaotang granules for type 2 diabetes mellitus complicated with coronary heart disease. Methods:A total of 64 cases of patients with type 2 diabetes mellitus complicated with coronary heart disease were divided into the observation group and the control group according to the random number table method, 31 and 33 cases in each group respectively. The control group was given routine treatment,and the observation group was additionally treated with Jianpi Xiaotang granules based on the treatment of the control group. The changes in activity of nuclear factor κB(NF-κB), fasting blood glucose(FBG), postprandial 2h blood glucose(P2hBG) and Chinese medicine syndrome scores before and after treatment in the two groups were observed. Results: Before treatment, there was no significant difference being found in the comparison of levels of FBG and P2hBG between the two groups(P>0.05). After treatment,the levels of FBG and P2hBG in the two groups were decreased when compared with those before treatment, and the two levels in the observation group were lower than those in the control group,differences being significant(P<0.05). Before treatment,when compared the activity of NF-κB and Chinese medicine syndrome scores between the two groups, there was no significance in the difference(P>0.05). After treatment,the activity of NF-κB and Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the activity and scores in the observation group were lower than those in the control group, differences being significant(P<0.05). Conclusion: In the treatment of patients with type 2 diabetes mellitus complicated with coronary heart disease, Jianpi Xiaotang granules can inhibit their activity of NF- κB,alleviate inflammatory responses,reduce the levels of FBG and P2hBG,and improve their clinical symptoms with good clinical effect.

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吴小秋,丁萍,张士晓,张凰,周钦云,孙静.健脾疏肝法治疗2型糖尿病合并冠心病临床研究[J].新中医,2020,52(19):84-87

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  • 在线发布日期: 2020-10-12
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