Abstract：Objective：To observe the clinical effect of acupoint application and Chinese herbal foot bathing combined with western medicine for depression concomitant with sleep disorders. Methods：Divided 126 cases of patients with depression concomitant with sleep disorders into the control group and the observation group randomly，62 cases in the control group and 64 cases in the observation group. Both groups received the oral administration of Mirtazapine tablets and Escitalopram Oxalate tablets as well as routine nursing measures； the observation group additionally received acupoint application and Chinese herbal foot bathing. The courses of treatment in both groups lasted for 4 weeks. Before and after treatment，evaluated the scores of Athens Insomnia Scale(AIS) and Insomnia Severity Index(ISI)， conducted examinations via polysomnography(PSG)，recorded the indexes of sleep latency，times of waking up，the total sleep time，sleep efficiency，times of rapid eye movement(REM) sleep，the time of REM sleep and the percentage of REM to the whole sleep time，and applied Treatment Emergent Symptoms Scale(TESS) to record the incidence and degree of adverse reactions during treatment. Results：After treatment，the clinical effect in the observation group was better than that in the control group(P＜0.05). The scores of AIS and ISI in both groups were decreased when compared with those before treatment(P＜0.01)，and the scores of AIS and ISI in the observation group were lower than those in the control group(P＜0.01). Sleep latency and the times of waking up in both groups were decreased when compared with those before treatment(P＜0.01)，and the total sleep time and sleep efficiency were increased when compared with those before treatment(P＜0.01). Sleep latency in the observation group was shorter than that in the control group，the times of waking up were more than those in the control group，and the total sleep time and sleep efficiency were increased when compared with those in the control group(P＜0.01).In the control group， the times of REM and the percentage of REM were increased， and the time of REM sleep was prolonged(P＜0.01)，while in the observation group，the times of REM and the percentage of REM were decreased，and the time of REM sleep was shortened(P＜0.01). The times of REM and the percentage of REM in the observation group were lower than those in the control group(P＜0.01)， and the time of REM sleep was shorter than that in the control group(P＜0.01). The incidence of adverse reactions was 20.31% in the observation group，being lower than 40.32% in the control group (P＜0.05). The scores of TESS in the observation group were lower than those in the control group(P＜0.01). Conclusion：Based on western medicine，acupoint application combined with herbal foot bathing has good effect in treating depression complicated with sleep disorder. It can effectively improve the quality of sleep，reduce the degree of insomnia and decrease the incidence and degree of adverse reactions，thus enhancing the clinical effect.