Abstract： Objective： To observe the clinical effect of Yiqi Huoxue Qinghua Lishui method for primary liver cancer.Methods：A total of 72 patients with primary liver cancer were randomly divided into the observation group and the control group，36 patients in each group. The control group was intervened with symptomatic treatment；the observation group was intervened with symptomatic treatment combined with Chinese herbs to invigorate qi，activate blood，and clear and remove as well as promote urination. The clinical effect and the changes of Chinese medicine syndrome score and the content of alpha-fetoprotein in serum in the two groups were observed and compared. Results：The total effective rate was 75.00% in the observation group and 41.67% in the control group，the difference being significant(P＜0.05). After treatment，the scores of abdominal distension， ascites， poor appetite， weakness， and flank pain in both groups were significantly decreased when compared with those before treatment(P＜0.05)； the scores of abdominal distention and ascites in the observation group were significantly lower than those in the control group(P＜0.05)，but there was no significant difference being found in the comparison of scores of poor appetite，weakness，and flank pain between the two groups(P＞0.05). After treatment，the levels of alpha-fetoprotein in both groups were significantly decreased when compared with those before treatment(P＜0.05)，and the level of alpha- fetoprotein in the observation group was significantly lower than that in the control group(P＜ 0.05). Conclusion： The Yiqi Huoxue Qinghua Lishui method for primary liver cancer， can effectively enhance the curative effect， improve the clinical symptoms of patients and inhibit the levels of alpha- fetoprotein， which is worthy of clinical application.