Abstract：Objective：To observe the curative effect of the therapy of internal and external application of modified Sihuang tang combined with acupuncture on senile patients with pain after procedure for prolapse and hemorrhoids(PPH) and its effect on vascular endothelial growth factor(VEGF)，interleukin-1β(IL-1β) and interferon-γ(IFN-γ) in serum. Methods：A total of 98 cases of senile patients after PPH were divided into two groups according to treatment methods，49 cases in each group.Both groups were given routine treatment after surgery； Group A was additionally treated with sitting bath of potassium permanganate solution，and Group B was additionally treated with internal and external application of modified Sihuang tang combined with acupuncture. The changes of VEGF， IFN- γ， IL- 1β， interleukin- 6(IL- 6) and the content of capillaries in wound were recorded before and after treatment， and the pain degree， hospitalization time， pain disappearance time，edema disappearance time，wound drainage disappearance time，wound healing time and adverse reactions were compared between the two groups. Results： There was no significant difference in the comparison of pain degree between the two groups on the day after surgery(P＞0.05). On the third and seventh days after surgery，the pain scores in the two groups were decreased when compared with those on the day after surgery(P＜0.05)，and the pain score in Group B was lower than that in Group A(P＜0.05). The hospitalization time， pain disappearance time， edema disappearance time and wound drainage disappearance time in Group B were shorter than those in Group A，the difference being significant(P＜0.05). On the day after surgery，there was no significant difference in the comparison of the levels of VEGF，IFN-γ，IL-1β and IL-6 between the two groups(P＞0.05). On the seventh day after surgery，the levels of VEGF and IFN-γ in both groups were increased when compared with those on the day after surgery，while levels of IL-1β and IL-6 decreased；the levels of VEGF and IFN-γ in Group B were higher than those in Group A，while levels of IL- 1β and IL-6 lower(P＜0.05). On the third and seventh days after surgery，the content of capillaries in wound in both groups were increased when compared with those on the day after surgery， and the content in Group B was more than that in Group A(P＜0.05). There was no significant difference in the comparison of the incidence of adverse reactions between Group B(6.12%) and Group A(10.20%)(P＞0.05). Conclusion：The therapy of internal and external application of modified Sihuang tang combined with acupuncture for senile patients with pain after PPH，can effectively reduce the pain degree，promote recovery and regulate the expression of related cytokines.