Abstract：Objective：To observe the clinical effect of Bailing capsules in adjuvant treatment of diabetic nephropathy(DN) and its effect on renal function index and micro-inflammatory state of patients. Methods：A total of 84 cases of DN patients were selected and divided into the control group and the observation group according to the random number table method，42 cases in each group. The control group was given symptomatic treatment including reducing blood sugar and blood pressure and regulating lipid；the observation group was additionally treated with Bailing capsules based on the treatment of the control group. Both groups were treated for three months. The clinical effectin the two groups was compared，and the improvement of renal function index as well as the levels of micro- inflammatory state were observed. Results：The total effective rate was 97.62% in the observation group， higher than that of 78.57% in the control group(P＜0.05). After treatment，the levels of blood urea nitrogen(BUN)，serum creatinine(SCr) in the two groups and the levels of β2-microglobulin (β2-MG)，blood uric acid(UA) in the observation group were all decreased when compared with those before treatment(P＜ 0.05)，and the levels of the above four renal function indexes in the observation group were all lower than those in the control group(P＜0.05). After treatment，the levels of tumor necrosis factor-α(TNF-α)，11-dehydrothromboxane B2(11-DH-TXB-2) in the two groups and the levels of hypersensitive C-reactive protein(hs-CRP)，high mobility group box protein B1(HMGB-1) in the observation group were all decreased when compared with those before treatment(P＜0.05)，and the levels of the above four inflammatory factors in the observation group were all lower than those in the control group(P＜0.05). Conclusion：The adjuvant therapy of Bailing capsules for DN can effectively improve the renal function and micro- inflammatory state of patients，and achieve good curative effect.