Abstract： Objective： To observe the clinical effect of modified Sanren tang and Xiehuang powder combined with western medicine for infantile anorexia of spleen-stomach damp-heat type. Methods：A total of 104 cases of children with anorexia of spleen-stomach dampness-heat type were selected and divided into the control group and the observation group according to the random number table method，52 cases in each group. The control group was treated with zinc gluconate oral solution and compound vitamin B， and the observation group was additionally treated with modified Sanren tang and Xiehuang powder based on the treatment of the control group. Both groups were treated for three weeks. The clinical effect，Chinese medicine syndrome scores，recovery time of appetite and food intake as well as the levels of hemoglobin and trace elements in the two groups were compared；the incidence of adverse reactions was recorded. Results：The total effective rate was 96.15% in the observation group，higher than that of 82.69% in the control group(P＜0.05). After treatment，the scores of poor appetite and torpid intake， fetid mouth odor and sticky tongue and dry stool in the two groups were all decreased when compared with those before treatment(P＜0.05)， and the scores of the above three Chinese medicine syndromes in the observation group were all lower than those in the control group(P＜0.05). The recovery time of appetite and food intake in the observation group was shorter than that in the control group(P＜0.05). After treatment， the levels of hemoglobin，blood zinc and blood calcium in the two groups were increased when compared with those before treatment(P＜0.05)， and the above levels in the observation group were all higher than those in the control group(P＜0.05). After administration，there was no obvious adverse reaction being found in the two groups. Conclusion：The therapy of modified Sanren tang and Xiehuang powder combined with western medicine for infantile anorexia of spleen- stomach dampnessheat type can effectively relieve the clinical symptoms of children， recover their appetite and food intake as soon as possible，and improve their nutritional status with good curative effect and safety.