半枝莲抗肿瘤作用及临床应用研究进展
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R285

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上海市科技支撑项目(16401902500);上海市中医引导科技支撑项目(19401933400);龙华医院科技创新项目(CX201836)


Research Progress on Anti-tumor Effect of Scutellaria Barbata and Its Clinical Applica⁃tion
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    摘要:

    半枝莲是治疗肿瘤的临床常用中药,其主要成分有木樨草素、芹黄素、槲皮苷、汉黄芩素、黄芩黄素、野黄芩素、黄芩苷、黄岑素等。被广泛应用于头颈部肿瘤、肺癌、乳腺癌、食管癌、胃癌、肝癌、胰腺癌、结直肠癌、卵巢癌、子宫内膜癌、宫颈癌、膀胱癌、黑色素瘤等肿瘤的治疗。现代中医发展了藤龙补中汤、肠复方、扶正消癌汤、肺泰胶囊和肺抑瘤膏等含有半枝莲的抗癌临床验方。同时有409 项含有半枝莲的抗癌专利,其中部分专利已转化为中成药,如养正消积胶囊、复方斑蝥胶囊、安康欣胶囊、蛇莲胶囊和抗癌平丸等。半枝莲治疗肿瘤的作用机制涉及抑制细胞增殖、诱导细胞自噬和凋亡、抑制转移、调节免疫功能和抑制肿瘤血管生成等。这些研究为合理应用半枝莲治疗肿瘤提供了基础。

    Abstract:

    Abstract:Scutellaria barbata is a commonly- used Chinese medicinal for tumor in clinical practice in Chinese medicine,whose main components comprise luteolin,apigenin,quercitrin,wogonin,baicalein,scutellarein,baicalin and baicalein.It is widely applied for treating tumors,such as head and neck tumors,lung cancer,esophageal cancer,gastric cancer,liver cancer, pancreatic cancer, colorectal cancer, ovarian cancer, endometrial cancer, cervical cancer, bladder cancer and melanoma. Modern Chinese medicine has developed numerous clinical anti- cancer proven prescriptions containing bearded scutellaria like Tenglong Buzhong tang,intestinal compound prescription,Fuzheng Xiao'ai tang,Feitai capsules and Feiyiliu ointment. Meanwhile, there are 409 anti- cancer patents containing scutellaria barbata, some of which have been transformed into Chinese patent medicine, including Yangzheng Xiaoji capsules, Fufang Banmao capsules, Ankangxin capsules, Shelian capsules and Kang'aiping pills. The functional mechanism of scutellaria barbata treating tumors is associated with inhibiting cell proliferation,inducing cell autophagy and apoptosis,inhibiting metastasis,regulating immune function and inhibiting tumor angiogenesis. These researches have provided the basis for the appropriate application of scutellaria barbata in treating tumors.

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陈雷,彭骁,胡兵.半枝莲抗肿瘤作用及临床应用研究进展[J].新中医,2020,52(10):14-18

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  • 在线发布日期: 2020-05-26
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