Abstract：Objective：To discuss the effect of Chinese medicine nursing techniques on complication rate，bad mood and stress indexes in patients with breast cancer after mastectomy. Methods：A total of 90 cases of patients with breast cancer were randomly divided into the control group and the observation group， 45 cases in each group. The control group was treated with routine nursing of western medicine，and the observation group was additionally treated with Chinese medicine nursing based on the treatment of the control group. The clinical effect and complication rates in the two groups were observed. Before and after nursing，the bad mood，quality of life and stress indexes in the two groups were compared. The compliance and nursing satisfaction in the two groups were compared. Results：The total effective rate was 86.67% in the observation group，significantly higher than that of 68.89% in the control group(P＜0.05). The complications in the two groups were mainly subcutaneous hydrops，lymphedema，wound disruption and skin flap necrosis，and the complication rate was 8.89% in the observation group， lower than that of 26.67% in the control group(P＜0.05). The scores of anxiety and depression in the observation group were lower than those in the control group(P＜0.05). The mental scores including social function，mental health，energy and emotional function，as well as the physical scores including physical pain，physiological function，physiological function and general health in the observation group were higher than those in the control group(P＜ 0.05). The stress indexes including norepinephrine，cortisol and epinephrine in the observation group were lower than those in the control group(P＜0.05). The compliance rate was 95.56% in the observation group， significantly higher than that of 77.78% in the control group(P＜0.05)； the nursing satisfaction was 97.78% in the observation group， significantly higher than that of 82.22% in the control group(P＜0.05). Conclusion：Chinese medicine nursing techniques in treating patients with breast cancer after mastectomy has good effect， which can significantly reduce complications and stress responses and improve bad mood and quality of life，with better compliance and nursing satisfaction.