Abstract：Objective：To observe the effect of tuina manipulation combined with medicine for myofascial pain syndrome. Methods： Enrolled 120 cases of patients with myofascial pain syndrome， and divided them into two groups according to random number table， 60 cases in each group. Both groups received the oral administration of Yaotong capsules and the external application of piroxicam gel， while the observation group additionally received tuina manipulation such as oblique pulling in waist， acupoint massage and tendon regulation. The courses of treatment in both groups lasted for one month. Before and after treatment，evaluated the degree of pain [Pain Rating Index(PRI)，the scores of Visual Analogue Scale(VAS) and Present Pain Intensity(PPI)] via the simplified Mc Gill Scale，measured the muscle thickness of psoas major and quadratus lumborum in the affected side via Color Doppler ultrasonic diagnostic apparatus，and evaluated the overall therapeutic effect. Results：After one month of treatment，the scores of PRI，PPI，and VAS in both groups were respectively lower than those before treatment(P＜0.05)，and the three scores above in the observation group were lower than those in the control group (P＜0.05). The muscle thickness values of psoas major and quadratus lumborum in both groups were higher than those before treatment(P＜0.05)，and the two values of muscle thickness in the observation group were higher than those in the control group(P＜0.05). The total effective rate was 81.67% in the control group and 96.67% in the observation group， difference being significant(P＜0.05). Conclusion： The additional application of tuina manipulation such as oblique pulling in waist， acupoint massage and tendon regulation based on medicine has better therapeutic advantage in treating patients with myofascial pain syndrome， which can effectively improve clinical symptoms like pain and signs， enhance muscle function and increase clinical effect.