Abstract： Objective： To discuss the clinical effect of Yangxue Huoxue Antai method for pre- thrombotic state of recurrent spontaneous abortion. Methods：A total of 86 cases of patients with pre-thrombotic state of recurrent spontaneous abortion were divided into the study group and the control group according to the random number table method，43 cases in each group. The control group was given routine western medicine， and the study group was additionally treated with Yangxue Huoxue Antai method based on the treatment of the control group. The clinical effect in the two groups was compared. The changes in coagulation indexes，fibrinolytic parameters and uterine arterial resistance values were detected. Results： The total effective rate was 90.7% in the study group， higher than that of 79.1% in the control group(P＜0.05). Before treatment， compared the levels of coagulation indexes including prothrombin time(PT)， thrombin time(TT) and activated partial thromboplastin time(APTT) in the two groups， there was no significance in the difference(P＞0.05). After treatment，the levels of PT and TT in the two groups were decreased when compared with those before treatment，and the levels of APTT were increased；the level of PT in the study group was lower than that in the control group，differences being significant(P＜0.05). Before treatment，compared the levels of fibrinolytic parameters including antithrombin Ⅲ(AT-Ⅲ)，Ddimer( D-D)，fibrinogen(FIB) between the two groups，there was no significance in the difference(P＞0.05). After treatment， the levels of AT-Ⅲ in the two groups were increased when compared with those before treatment，and the levels of D-D and FIB were decreased；the level of AT-Ⅲ in the study group was higher than that in the control group，and the levels of D-D and FIB were lower than those in the control group ； differences being significant(P ＜ 0.05). Before treatment ， compared the left RI value， right RI value， and the sum of bilateral S/D values between the two groups， there was no significance in the difference(P＞0.05). After treatment，the left RI value，right RI value，and the sum of bilateral S/D values in the two groups were decreased when compared with those before treatment，and the above values in the study group were all lower than those in the control group；differences being significant(P＜0.05). Conclusion：In the treatment of prethrombotic state of recurrent spontaneous abortion， the Yangxue Huoxue Antai method can effectively relieve coagulation and fibrinolysis of pregnant women，enhance the cure effective rate，and improve pregnancy outcome，which is worthy of clinical application.