Abstract： Objective： To observe the clinical effect of Shugan Jieyu granules combined with escitalopram oxalate for depression and its effect on factors of nerve function. Methods： A total of 62 cases of patients with depression were randomly divided into the western medicine group and the integrated Chinese and western medicine group，31 cases in each group. The western medicine group was treated with escitalopram oxalate tablets，and the integrated Chinese and western medicine group was additionally treated with Shugan Jieyu granules based on the treatment of the western medicine group. The scores of Hamilton Depression Scale(HAMD) and the changes of correlation factors of nerve function including S100B protein and myelin basic protein(MBP) before and after treatment，as well as the total clinical effect and adverse reactions in the two groups were observed and compared. Results：The total effective rate was 93.54% in the integrated Chinese and western medicine group and 74.19% in the western medicine group， the difference being significant(P＜0.05). After treatment for four and eight weeks，the HAMD scores in the two groups were significantly decreased when compared with those before treatment(P＜0.05)；the decrease in the integrated Chinese and western medicine group was more significant than that in the western medicine group(P＜0.05). After treatment for eight weeks，the levels of S100B and MBP in the two groups were significantly decreased when compared with those before treatment(P＜0.05)；but no significant difference was found in the comparison of the above levels between the two groups(P＞0.05). The incidence of adverse reactions was 12.90% in the integrated Chinese and western medicine group and 16.12% in the western medicine group，there being no significance in the difference(P＞0.05). Conclusion： Based on the treatment of escitalopram oxalate tablets， the additional application of Shugan Jieyu granules in treating depression can effectively improve clinical effect and depression state， without increasing adverse reactions of medicines.